A ultrassonografia geralmente é o primeiro exame por imagem a ser realizado em caso de estudo das glândulas salivares e tireoide. Serve tanto para avaliar suas dimensões, detectar lesões, localizar e classificar os nódulos. Nesse exame são estudadas as glândulas parótidas, submandibulares, sublinguais, tireoide e os níveis cervicais.
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